Preface
Acknowledgements
Dedication
PartⅠ:Processes of Metabolism and Nutrition
1.Overview of Metabolism
Useful definitions
Basic principles of bioenergetics
2.Carbohydrate and Energy Metabolism
Glycolysis and its regulation
Central role of acetyl CoA
Tricarboxylic acid cycle (TCA Cycle)
Generation of ATP
Glycogen metabolism
Role of 2,3-bisphosphoglycerate
Fructose,galactose,ethanol,and sorbitol
3.Production of NADPH
Pentose phosphate pathway and the pyruvatemalate cycle
The roles of NADPH
4.Lipid Metabolism
Lipid biosynthesis
Lipid breakdown
Cholesterol metabolism
Transport of lipids
The ketone bodies
5.Protein Metabolism
Biosynthesis of the non-essential amino acids
Protein breakdown and the disposal of nitrogen
Gluconeogenesis and the metabolism of amino acids to glucose and fat
Amino acid metabolism in individual tissues
6.Purines,Pyrimidines,and Haem
One-carbon pool
Purine metabolism
Pyrimidine metabolism
Haem metabolism
7.Metabolic Integration
Glucose homeostasis
8.Nutrition
Basic principles of human nutrition
Energy balance
Protein nutrition
Vitamins
Minerals
PartⅡ:Clinical Assessment
9.Taking a History
Things to remember when taking a history
Common presenting complaints
10.Examination of the Patient
General inspection
Limbs
Head and neck
Thorax
The abdomen
11.Further Investigations
Routine investigations
Assessment of nutritional status
PartⅢ:Basic Pathology
12.Important Metabolic Disorders
Disorders of glucose and energy metabolism
Disorders of lipid metabolism
Disorders of amino acid metabolism
Disorders of purine pyrimidine metabolism
Disorders of haem metabolism
13.Important Nutritional Disorders
Disorders of protein nutrition and energy balance
The fat-soluble vitamins:deficiency and excess
The water-soluble vitamins:effects of deficiency
Disorders of mineral nutrition
PartⅣ:Self-assessment
Multiple-choice Questions
Short-answer Questions
Essay Questions
MCQ Answers
SAQ Answers
Index
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