代谢与细胞工程导论（国外生命科学优秀教材 影印版）

Preface
ListofAbbreviations
Introduction
IntroductoryOutlines
MetabolicandCellularEngineeringintheContextofBioprocessEngineering
ToolsforMetabolicandCellularEngineering
EngineeringCellsforSpecificBiotransformations
MetabolicAreasthatHaveBeenSubjectedtoMCE
FromDNASequencetoBiologicalFunction
TemporalandSpatialScalinginCellularProcesses
ScalinginMicrobialandBiochemicalSystems
ViewsoftheCell
TransductionandIntracellularSignalling
Self-organizedEmergentPhenomena
HomeodynamicsandCoherence
MatterandEnergyBalances
MassBalance
EnergyBalance
CellGrowthandMetaboliteProduction.BasicConcepts
MicrobialGrowthunderSteadyandBalancedConditions
MicrobialEnergeticsunderSteadyStateConditions
GrowthKineticsunderSteadyStateConditions
TheDilutionRateandtheGrowth-limitingSubstrateConcentration
BionmassandGrowth-limitingSubstrateConcentrationattheSteadyState
GrowthasaBalanceofFluxes
TheFluxCoordinationHypothesis
TowardaRationalDesignofCells
RedirectingCentralMetabolicPathwaysunderKineticorThermodynamicControl
ThermodynamicorKineticControlofFluxunderSteadyStateConditions
KineticandThermodynamicLimitationsinMicrobialSystems.CaseStudies
IncreasingCarbonFlowtoAromaticBiosynthesisinEschericahiacoli
MethodsofQuantitationofCellular"ProcessesPerformance"
StoichiometryofGrowth：TheEquivalencebetweenBiochemicalStoichiometriesandphysiologicalParameters
AGeneralFormalismforMetabolicFluxAnalysis
AComparisonbetweenDifferentMethodsofMFA
MetabolicFluxesduringBalancedandSteadyStateGrowth
BioenergeticandPhysiologicalStudiesinBatchandContinuousCultures.GeneticorEpigeneticRedirectionofMetabolicFlux
MetabolicControlAnalysis
ControlandRegulation
TheControlofMetabolitesConcentration
TheTDAApproachasAppliedtotheRationalDesignofMicroorganisms：IncreaseofEthanolProductioninYeast
AppendixA
AppendixB
DynamicAspectsofBioprocessBehavior
TransientandOscillatoryStatesofContinuousCulture
MathematicalModelBuilding
TransientResponsesofMicrobialCulturestoPerturbationsoftheSteadyState
OscillatoryPhenomenainContinuousCultures
BioprocessDevelopmentwithPlantCells
MCEinPlants：RealitiesandPotentialities
ImprovingPlantsthroughGeneticEngineering
UsingPlantGeneticEngineeringtoProduceHeterologousProteins
ToolsfortheManipulationandTransformationofPlants
PlantMetabolism：MatterandEnergyFlowsandtheProspectsofMCA
MetabolicCompartmentationinPlantCells
CarbonAssimilation,PartitioningandAllocation
Carbonfixationinhigherplants
MCAStudiesinPlants
RegulationandControl：StarchSynthesis,aCaseStudy
ConcludingRemarks
CellularEngineering
Outline
TheGlobalFunctioningofMetabolicNetworks
CellularEngineering
GrowthRate,G1PhaseoftheCellCycle,ProductionofMetabolitesandMacromoleculesasTargetsforCellularEngineering
CataboliteRepressionandCellCycleRegulationinYeast
ProteinProductionasaFunctionofGrowthRate
TheSelectiveFunctioningofWholeMetabolicPathwaysisPermissiveforDifferentiation
Bibliography
Index