Contents
1 Fundamentals on Bionanotechnologies 1
1.1 TransportPhenomenaattheNanoscale 1
1.2 Nanotechnologiesfor BionanoelectronicDevices 18
1.2.1 Deposition Techniques for BionanoelectronicDevices 18
1.2.2 Nanolithography 20
1.2.3 Nanomaterials 27
1.3 Conduction Properties of BiologicalMaterials 35
1.4 Micro.uidics and Nano.uidics 46
References 54
2 Sensing of Biomolecules 57
2.1 Nanotransistors Based on Nanotubes, Nanowires, andGrapheneforBiosensing 57
2.2 DNA Detection and SequencingUsing Nanopores 73
2.3 MEMS/NEMS Biodetection 80
2.4 Plasmonics Biodetection 87
2.5 NanoelectronicNoses and Various Disease Detection 98
References 102
3 Imaging and Manipulation of Biomolecules 107
3.1 Bioapplications of Atomic Force Microscopy 107
3.2 Bioapplicationsof Scanning TunnelingMicroscopy 114
3.3 ManipulationofBiologicalMaterials 117
References 123
4 Nanomedicine 127
4.1 Drug Deliveryand Healing Based on Nanomaterials 127
4.2 Biochips—DNAArraysandOtherChipsforDiagnosis 144
4.3 Arti.cial Tissues and Organs 146
References 148
5 Biomolecular Architecture for Nanotechnology 151
5.1 DNA-BasedMolecularArchitectures 152
5.2 Self-Assembled DNA Nanowires 155
5.3 Two-and Three-DimensionalBioarchitectures as Scaffolds 159
5.4 NonperiodicBiologicalScaffoldsforInorganicStructures 165
5.5 InorganicScaffolds for Biomolecules 169
References 170
6 Biomolecular Machines 173
6.1 BiologicalActuatorsandSwitches 174
6.2 Biological Walkers 180
6.3 Biological Motors 183
References 187
7 Biomolecular Computing 189
7.1 Principles of Biomolecular Computing 189
7.2 Boolean BiomolecularComputing 192
7.3 Self-AssemblyBiomolecularComputing 198
7.4 Biomolecular Logical Deductions 200
7.5 Biomolecular Memory Devices 201
7.6 Logical Drug Delivery and In Vivo Computation 203
References 205
8 Bioinspired Devices 207
8.1 Bioinspired Materials 208
8.2 Bioinspired Devices 215
8.3 Bioinspired TechnologicalProcesses 222
8.4 Devices Mimicking Biological Organs/Functionalities 224
References 229
9 Nano-Bio Integration 233
9.1 Nano-bioMaterials for Electronics and Optoelectronics 233
9.2 Nano-bioMechanical Devices 236
9.3 Nanobioelectronicsand Optoelectronics 239
References 246
Index 249
About the Authors 253