Colorectal cancer is a common source of morbidity and mortality, and as such merits study across the spectrum of its epidemiology, biology and therapy This book aims to provide an integrated and comprehensive approach to colorectal cancer control, delivered by internationally well known and respected authors who write with clarity and authority. Rather than focus on a single topic, say genetics, we considered it important to cover all elements of disease control, given how interelated and interdisciplinary medical science has become. If we are to prevent colorectal cancer, we must first understand its aetiology and biology, describe the role of population registries in monitoring incidence and death rates to assess the impact of screening and therapy, develop molecular models of carcinogenesis which can yield novel targets for drug development.