蛇葡萄素和运动模拟剂在慢性疾病中的生物功能及机制

The Biological Function and Molecular Mechanism of Ampelopsin and Exercise Mimetics in Chronic DiseasesContentsChapter 1Pharmacological potential of ampelopsin in Rattan tea1 Chapter 2Ampelopsin reduces endotoxic inflammation via repressing ROSmediated activation of PI3K/Akt/NFκB signaling pathways8 Chapter 3Natural products for cancer prevention associated with Nrf2ARE pathway23 Chapter 4Antitumor effect31 4.1Potential molecular targets of ampelopsin in prevention and treatment of cancers31 4.2Nutraceutical or pharmacological potential of Moringa oleifera Lam.39 4.3Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways：involvement of p38 and ERK48 Chapter 5Neuroprotective effect59 5.1Ampelopsin inhibits H2O2induced apoptosis by ERK and Akt signaling pathways and upregulation of heme oxygenase159 5.2Ampelopsin attenuates 6OHDAinduced neurotoxicity by regulating GSK3β/NRF2/ARE signaling67 Chapter 6Autophagy and brain aging77 6.1Autophagy as the modulator of neuronal homeostasis and neurodegenerative disorders77 6.2Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer’s disease80 6.3Ampelopsin attenuates brain aging of Dgalinduced rats through miR34amediated SIRT1/mTOR signaling pathway89 6.4Swimming attenuates Dgalactoseinduced brain aging via suppressing miR34amediated autophagy impairment and abnormal mitochondrial dynamics101 6.5Voluntary wheel running exercise suppresses brain aging of rats through activating miR130amediated autophagy112 Chapter 7Sarcopenia123 7.1Research progress of sarcopenia123 7.2MicroRNAregulated proinflammatory cytokines in sarcopenia127 7.3Ampelopsin attenuates Dgalinduced oxidative stressrelated skeletal muscle atrophy through activating AMPK/SIRT1/PGC1α signaling cascade135 7.4Role and regulation of autophagy in mass maintenance of skeletal muscle147 Acknowledgement155 References156