The Kashgar region has been the transportation hub on the Silk Road since ancient times.With its splendid history and cultures created by the multi-ethnic groups,it is one of the important bridge-heads of the Silk Road Economic Belt jointly constructed by China,Central Asian and South Asian countries. However,the region is one of the severely impoverished areas in the southern part of Xinjiang Uyghur Autonomous Region. Problems such as poverty,backwardness and lack of information are becoming the major obstacles which constrain the economic,social sustainable development of counties and cities in the Kashgar region,thus eliminating the motives of tuming its traditional strength in geography,humanity,history and culture into development opporiunities. Since the beginning of targeted poverty alleviation project,the Kashgar region has made excellent development in poverty alleviation,which features its own characteristics,prominence in achievement and excellence in results after it has firmly taken an approach of development driving poverty alleviation and poverty elimination and accurately targeted the meeting point among the national policies,policy dividends,features and demands of its own development route.Achievement in poverty alleviation in the Kashgar region not only generates powerful endogenous momentum for economic and social upgrade in counties and cities in the new era,but also further deepens the community sense of the Chinese nation developed in the process of the Prefecture's role of leading every ethnic group to achieve common prosperity and to strive for a relatively comfortable life,which has contributed to the unity of ethnic groups and the stability in border areas. This paper looks at the overall development of poverty alleviation in the Kashgar Region during the period of the 13th Five-Year Plan(2016~2020),chooses Tashkurghan County(the only county located in the Pamir Plateau) and Yecheng County(a representative case of thefour counties which are yet taken out of poverty in the oasis of Kashgar )as case studies,and makes a reasonable review of and introduces the developmental approaches,measures and achievement of the poverty alleviation,providing empirical case study evidence and observation angles for the systematic understanding of the opportunities and challenges in the Kashgar region when achieving the full victory in building a well-off society.