This book constitutes the refereed proceedings of the 7th International Conference on Product-Focused Software Process Improvement, PROFES 2006, held in Amsterdam, The Netherlands in June 2006.The 26 revised full papers and 12 revised short papers presented together with 6 reports on workshops and tutorials were carefully reviewed and selected from 55 submissions. The papers constitute a balanced mix of academic and industrial aspects; they are organized in topical sections on decision support, embedded software and system development, measurement, industrial experience, process improvement, agile development practices, and product line engineering.